Is there any drug for topical application on vegina before first ?

I think you're asking for something that will help avoid pain for the woman? Certainly, you could purchase some over-the-counter lubricant, such as KY Jelly. However, if you take your time to be sure that both of you are truly stimulated and ready, there should be no need for any added product. A woman's body is made to create its own lubricant, when treated properly, so just be a loving partner, and you should be fine.